Influence of Tissue Specific Macromolecule Baseline on the Metabolite Quantification in Human Brain at 7 Tesla
نویسندگان
چکیده
Fig. 3: Metabolite concentration (mean±sem., n=5) of H spectra acquired in white matter region using the MM baseline measured in white matter (red) or grey matter blue). Significant changes are obersved for Gln, Glu, NAA, Asp. 3496 INFLUENCE OF TISSUE SPECIFIC MACROMOLECULE BASELINE ON THE METABOLITE QUANTIFICATION IN HUMAN BRAIN AT 7 TESLA Benoit Schaller, Lijing Xin, and Rolf Gruetter Laboratory of Functional and Metabolic Imaging, Ecole Polytechnique Federale de Lausanne, Lausanne, Vaud, Switzerland, Department of Radiology, University of Lausanne, Lausanne, Switzerland, Laboratory of Functional and Metabolic Imaging, Ecole Polytechnique Federale de Lausanne, Lausanne, Switzerland
منابع مشابه
Is the macromolecule signal tissue-specific in healthy human brain? A (1)H MRS study at 7 Tesla in the occipital lobe.
PURPOSE The macromolecule signal plays a key role in the precision and the accuracy of the metabolite quantification in short-TE (1) H MR spectroscopy. Macromolecules have been reported at 1.5 Tesla (T) to depend on the cerebral studied region and to be age specific. As metabolite concentrations vary locally, information about the profile of the macromolecule signal in different tissues may be ...
متن کاملQuantification Differences of H Spectra in Human Brain at 3 Tesla Using the Acquired Macromolecule Baseline or the Built-in Lcmodel Spline Baseline
Fig. 2.A) H NMR spectra (top, n=64) with the built-in LC Model spline baseline (A). Fig. 2.B) H NMR spectra (top, n=64) with the in-vivo acquired MM baseline (n=3, 384 scans) after correction (middle) and the residual (bottom). The curves are represented as the mean (red) ± standard deviation (shadow). Substantial differences in the shape of the baseline between the spline and acquired MM can b...
متن کاملInfluence of regional macromolecule baseline on the quantification of neurochemical profile in rat brain
Introduction Prior knowledge of the macromolecule baseline is important for the accurate quantification of metabolite concentrations from in vivo H NMR spectra acquired at short echo times (TE) [1]. Macromolecules may be altered due to pathology [2]. In contrast, regional alterations of macromolecule baseline in rat brain have not been studied, although the neurochemical profile varies strongly...
متن کاملQuantification of the neurochemical profile using simulated macromolecule resonances at 3 T.
The broad resonances underlying the entire (1) H NMR spectrum of the brain, ascribed to macromolecules, can influence metabolite quantification. At the intermediate field strength of 3 T, distinct approaches for the determination of the macromolecule signal, previously used at either 1.5 or 7 T and higher, may become equivalent. The aim of this study was to evaluate, at 3 T for healthy subjects...
متن کاملIn vivo brain macromolecule signals in healthy and glioblastoma mouse models: 1H magnetic resonance spectroscopy, post-processing and metabolite quantification at 14.1 T.
In (1)H magnetic resonance spectroscopy, macromolecule signals underlay metabolite signals, and knowing their contribution is necessary for reliable metabolite quantification. When macromolecule signals are measured using an inversion-recovery pulse sequence, special care needs to be taken to correctly remove residual metabolite signals to obtain a pure macromolecule spectrum. Furthermore, sinc...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2011